|
Sjogren's Syndrome
|
0.070 |
Biomarker
|
disease |
BEFREE |
Animal models suggest that early markers of Sjögren syndrome (EMS)-antibodies against salivary protein 1, parotid secretory protein, and carbonic anhydrase 6 (CA6)-are more accurate signals of early Sjögren when compared with classic markers (anti-Ro and anti-La).
|
31634227 |
2020 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Neurogranin was decreased in PD, PD with dementia, MSA, and PSP compared to controls and Alzheimer's disease.
|
31837067 |
2020 |
|
Progressive supranuclear palsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary spontaneous pneumothorax (PSP) generally occurs in young adults, whereas pediatric PSP is uncommon.
|
30955098 |
2019 |
|
Progressive supranuclear palsy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Objectives:</b> The present study is geared to learning about the patterns of tau seeding and cells involved following unilateral inoculation in the corpus callosum of homogenates from sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau and 3Rtau), pure aging-related tau astrogliopathy (ARTAG: astroglial 4Rtau with thorn-shaped astrocytes TSAs), globular glial tauopathy (GGT: 4Rtau with neuronal tau and specific tau inclusions in astrocytes and oligodendrocytes, GAIs and GOIs, respectively), progressive supranuclear palsy (PSP: 4Rtau with neuronal inclusions, tufted astrocytes and coiled bodies), Pick's disease (PiD: 3Rtau with characteristic Pick bodies in neurons and tau containing fibrillar astrocytes), and frontotemporal lobar degeneration linked to P301L mutation (FTLD-P301L: 4Rtau familial tauopathy).
|
31191295 |
2019 |
|
Progressive supranuclear palsy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The overall sensitivity of the International Parkinson and Movement Disorder Society criteria was 87.9%, compared with 45.5% for the National Institutes of Neurological Disease and Society for Progressive Supranuclear Palsy criteria, whereas the specificity of the International Parkinson and Movement Disorder Society probable PSP criteria was 85.7%, compared with 90.5% for the National Institutes of Neurological Disease and Society for Progressive Supranuclear Palsy.
|
30726566 |
2019 |
|
Sjogren's Syndrome
|
0.070 |
Biomarker
|
disease |
BEFREE |
Recently, the presence of novel tissue specific autoantibodies (TSAs), SP-1, CA6, and PSP, has been observed in the early stages of SS.
|
30572137 |
2019 |
|
Sjogren's Syndrome
|
0.070 |
Biomarker
|
disease |
BEFREE |
In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS.
|
31517725 |
2019 |
|
Parkinson Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Using a PSP genetic risk score (GRS), we showed that the genetic risk burden in the EOPSP (mean z-score, 0.59) and LOPSP (mean z-score, 0.48) groups was significantly higher (P < 0.05) when compared with the PD group (mean z-score, -0.08).
|
31299107 |
2019 |
|
Alzheimer's Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
<b>Objectives:</b> The present study is geared to learning about the patterns of tau seeding and cells involved following unilateral inoculation in the corpus callosum of homogenates from sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau and 3Rtau), pure aging-related tau astrogliopathy (ARTAG: astroglial 4Rtau with thorn-shaped astrocytes TSAs), globular glial tauopathy (GGT: 4Rtau with neuronal tau and specific tau inclusions in astrocytes and oligodendrocytes, GAIs and GOIs, respectively), progressive supranuclear palsy (PSP: 4Rtau with neuronal inclusions, tufted astrocytes and coiled bodies), Pick's disease (PiD: 3Rtau with characteristic Pick bodies in neurons and tau containing fibrillar astrocytes), and frontotemporal lobar degeneration linked to P301L mutation (FTLD-P301L: 4Rtau familial tauopathy).
|
31191295 |
2019 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
N-224 tau concentrations in PSP and CBS were significantly lower than in AD (p < 0.0001) and did not correlate to t-tau and p-tau.
|
30547227 |
2019 |
|
Tauopathies
|
0.050 |
GeneticVariation
|
group |
BEFREE |
<b>Objectives:</b> The present study is geared to learning about the patterns of tau seeding and cells involved following unilateral inoculation in the corpus callosum of homogenates from sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau and 3Rtau), pure aging-related tau astrogliopathy (ARTAG: astroglial 4Rtau with thorn-shaped astrocytes TSAs), globular glial tauopathy (GGT: 4Rtau with neuronal tau and specific tau inclusions in astrocytes and oligodendrocytes, GAIs and GOIs, respectively), progressive supranuclear palsy (PSP: 4Rtau with neuronal inclusions, tufted astrocytes and coiled bodies), Pick's disease (PiD: 3Rtau with characteristic Pick bodies in neurons and tau containing fibrillar astrocytes), and frontotemporal lobar degeneration linked to P301L mutation (FTLD-P301L: 4Rtau familial tauopathy).
|
31191295 |
2019 |
|
PNEUMOTHORAX, PRIMARY SPONTANEOUS
|
0.040 |
Biomarker
|
disease |
BEFREE |
Primary spontaneous pneumothorax (PSP) generally occurs in young adults, whereas pediatric PSP is uncommon.
|
30955098 |
2019 |
|
Dry Eye Syndromes
|
0.030 |
Biomarker
|
disease |
BEFREE |
In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS.
|
31517725 |
2019 |
|
Pick Disease of the Brain
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
<b>Objectives:</b> The present study is geared to learning about the patterns of tau seeding and cells involved following unilateral inoculation in the corpus callosum of homogenates from sporadic Alzheimer's disease (AD), primary age-related tauopathy (PART: neuronal 4Rtau and 3Rtau), pure aging-related tau astrogliopathy (ARTAG: astroglial 4Rtau with thorn-shaped astrocytes TSAs), globular glial tauopathy (GGT: 4Rtau with neuronal tau and specific tau inclusions in astrocytes and oligodendrocytes, GAIs and GOIs, respectively), progressive supranuclear palsy (PSP: 4Rtau with neuronal inclusions, tufted astrocytes and coiled bodies), Pick's disease (PiD: 3Rtau with characteristic Pick bodies in neurons and tau containing fibrillar astrocytes), and frontotemporal lobar degeneration linked to P301L mutation (FTLD-P301L: 4Rtau familial tauopathy).
|
31191295 |
2019 |
|
Dryness of eye
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS.
|
31517725 |
2019 |
|
Diabetes
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
PSP/reg levels are elevated in cell culture and mouse models of Wolfram syndrome, a prototype of ER stress-induced diabetes.
|
30914711 |
2019 |
|
Diabetes Mellitus
|
0.020 |
AlteredExpression
|
group |
BEFREE |
PSP/reg levels are elevated in cell culture and mouse models of Wolfram syndrome, a prototype of ER stress-induced diabetes.
|
30914711 |
2019 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
The overall sensitivity of the International Parkinson and Movement Disorder Society criteria was 87.9%, compared with 45.5% for the National Institutes of Neurological Disease and Society for Progressive Supranuclear Palsy criteria, whereas the specificity of the International Parkinson and Movement Disorder Society probable PSP criteria was 85.7%, compared with 90.5% for the National Institutes of Neurological Disease and Society for Progressive Supranuclear Palsy.
|
30726566 |
2019 |
|
Bradykinesia
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Subsequently, the diagnosis was changed to PSP due to hypometric downward gaze, reduced blink frequency, symmetric bradykinesia, rigidity, and the absence of autonomic dysfunction.
|
31216016 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Analyzing the capability of PSP, PCT and sCD25 to support the diagnosis of infection in cancer patients with febrile neutropenia.
|
30240355 |
2019 |
|
Dysautonomia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, the diagnosis was changed to PSP due to hypometric downward gaze, reduced blink frequency, symmetric bradykinesia, rigidity, and the absence of autonomic dysfunction.
|
31216016 |
2019 |
|
Myotonic Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report a patient with the coexistence of PSP with pontocerebellar atrophy and myotonic dystrophy type 1 (DM1).
|
31216016 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Aim:</b> To assess the prognostic value for 28-day mortality of PSP in critically ill patients with sepsis.
|
31621373 |
2019 |
|
Wolfram Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Circulating PSP/reg levels are also increased in some patients with Wolfram syndrome.
|
30914711 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Aim:</b> To assess the prognostic value for 28-day mortality of PSP in critically ill patients with sepsis.
|
31621373 |
2019 |